ALEY, K.O.; LEVINE, J.D. Role of protein kinase A in the maintenance of infl ammatory pain. J. Neurosci., v.19, n.6, p.2181-2186, 1999.

ALEY, K.O. et al. Chronic hypersensitivity for infl ammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J. Neurosci., v.20, n.12, p.4680-4685, 2000.

BATTAGLIA, G.; RUSTIONI, A. Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey. J. Comp. Neurol., v.277, n.2, p.302-312, 1988.

BESSON, J.M.; CHAOUCH, A. Peripheral and spinal mechanisms of nociception. Physiol. Rev., v.67, n.1, p.67-186, 1987.

BONICA, J. The management of pain. Philadelphia: Lea & Febiger, 1990.

CASTRO, M.S.A.; FERREIRA, S.H. Cell migration and hyperalgesia: a paradoxical effect of endotoxin. In: ADVANCES in infl ammation research. New York: Raven, 1979.

COUTAUX, A. et al. Hyperalgesia and allodynia: peripheral mechanisms. Joint Bone Spine, v.72, n.5, p.359-371, 2005.

CUNHA, F.Q. et al. Interleukin-8 as a mediator of sympathetic pain. Br. J. Pharmacol., v.104, n.3, p.765-767, 1991.

CUNHA, F.Q. et al. The pivotal role of tumour necrosis factor alpha in the development of infl ammatory hyperalgesia. Br. J. Pharmacol., v.107, n.3, p.660-664, 1992.

CUNHA, J.M. et al. The critical role of leukotriene B4 in antigeninduced mechanical hyperalgesia in immunised rats. Br. J. Pharmacol., v.139, n.6, p.1135-1145, 2003.

CUNHA, T.M. et al. A cascade of cytokines mediates mechanical infl ammatory hypernociception in mice. Proc. Natl. Acad. Sci. USA, v.102, n.5, p.1755-1760, 2005.

DEVOR, M. Unexplained peculiarities of the dorsal root ganglion. Pain, p.S27-35, 1999. Suppl. 6.

DÍAZ-GONZÁLEZ, F. et al. Clinical trial of a leucotriene B4 receptor antagonist, BIIL 284, in patients with rheumatoid arthritis. Ann. Rheum. Dis., v.66, n.5, p.628-632, 2007.

DUBNER, R.; BENNETT, G.J. Spinal and trigeminal mechanisms of nociception. Annu. Rev. Neurosci., v.6, p.381- 418, 1983.

DUBNER, R. et al. The correlation of monkey medullary dorsal horn neuronal activity and the perceived intensity of noxious heat stimuli. J. Neurophysiol., v.62, n.2, p.450-457, 1989.

FERREIRA, S.H. Peripheral analgesic sites of action of antiinfl ammatory drugs. Int. J. Clin. Pract. Suppl., n.128, p.2-10, 2002.

_____. Prostaglandins, aspirin-like drugs and analgesia. Nat. New Biol., v.240, n.102, p.200-203, 1972.

_____. The role of interleukins and nitric oxide in the mediation of infl ammatory pain and its control by peripheral analgesics. Drugs, v.46, p.1-9, 1993. Suppl. 1.

FERREIRA, S.H.; NAKAMURA, M.I. Prostaglandin hyperalgesia, a cAMP/Ca2+ dependent process. Prostaglandins, v.18, n.2, p.179-190, 1979.

FERREIRA, S.H.; LORENZETTI, B.B.; CAMPOS, D.I. Induction, blockade and restoration of a persistent hypersensitive state. Pain, v.42, n.3, p.365-371, 1990.

FERREIRA, S.H.; LORENZETTI, B.B.; POOLE, S. Bradykinin initiates cytokine-mediated infl ammatory hyperalgesia. Br. J. Pharmacol., v.110, n.3, p.1227-1231, 1993.

FERREIRA, S.H. et al. Bradykinin release of TNF-alpha plays a key role in the development of infl ammatory hyperalgesia. Agents Actions, v.38, C7-9, 1993. Número especial.

FERREIRA, S.H. et al. Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature, v.334, n.6184, p.698-700, 1988.

FERREIRA, S.H. et al. Role of lipocortin-1 in the antihyperalgesic actions of dexamethasone. Br. J. Pharmacol., v.121, n.5, p.883-888, 1997.

HARDY, J.D.; WOLFF, H.G.; GOODELL, H. Experimental evidence on the nature of cutaneous hyperalgesia. J. Clin. Invest., v.29, n.1, p.115-140, 1950.

JU, G. et al. Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells. Cell Tissue Res., v.247, n.2, p.417-431, 1987.

LAI, J. et al. Voltage-gated sodium channels and hyperalgesia. Annu. Rev. Pharmacol. Toxicol., v.44, p.371-397, 2004.

LEVINE, J.D. et al. Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes. Science, v.225, n.4663, p.743-745, 1984.

LEVINE, J.D. et al. The role of the polymorphonuclear leukocyte in hyperalgesia. J. Neurosci., v.5, n.11, p.3025-3029, 1985.

LORENZETTI, B.B. et al. Cytokine-induced neutrophil chemoattractant 1 (CINC-1) mediates the sympathetic component of infl ammatory mechanical hypersensitivitiy in rats. Eur. Cytokine Netw., v.13, n.4, p.456-461, 2002.

MCMAHON, S.; KOLTZENBURG, M. The changing role of primary afferent neurones in pain. Pain, v.43, n.3, p.269-272, 1990.

MILLAN, M.J. The induction of pain: an integrative review. Prog. Neurobiol., v.57, n.1, p.1-164, 1999.

MILNE, R.J. et al. Convergence of cutaneous and pelvic visceral nociceptive inputs onto primate spinothalamic neurons. Pain, v.11, n.2, p.163-183, 1981.

NAKAMURA, M.; FERREIRA, S.H. A peripheral sympathetic component in infl ammatory hyperalgesia. Eur. J. Pharmacol., v.135, n.2, p.145-153, 1987.

NOBACK, C.R.; STROMINGER, N.L.; DEMAREST, R.J. The human nervous system structure and function. New York: Williams & Wilkins, 1996.

PARADA, C.A. et al. Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fi bers causes retrograde mechanical nociceptor sensitization. Proc. Natl. Acad. Sci. USA, v.100, n.5, p.2923-2928, 2003.

PRADO, W. Medicamentos analgésicos de ação central. In: GRAEFF, F.G.; GUIMARÃES, F. S. Fundamentos de psicofarmacologia. São Paulo: Atheneu, 1999.

RANG, H.P.; BEVAN, S.; DRAY, A. Chemical activation of nociceptive peripheral neurones. Br. Med. Bull., v.47, n.3, p.534-548, 1991.

REXED, B. A cytoarchitectonic atlas of the spinal cord in the cat. J. Comp. Neurol., v.100, n.2, p.297-379, 1954.

_____. The cytoarchitectonic organization of the spinal cord in the cat. J. Comp. Neurol., v.96, n.3, p.414-495, 1952.

RIBEIRO, R.A. et al. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur. J. Pharmacol., v.387, n.1, p.111-118, 2000.

SACHS, D.; CUNHA, F.Q.; FERREIRA, S.H. Peripheral analgesic blockade of hypernociception: activation of arginine/NO/ cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc. Natl. Acad. Sci. USA, v.101, n.10, p.3680-3685, 2004.

SACHS, D. et al. Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity. Pain, v.96, n.1-2, p.89-97, 2002.

SCHAIBLE, H.G.; SCHMIDT, R.F. Time course of mechanosensitivity changes in articular afferents during a developing experimental arthritis. J. Neurophysiol., v.60, n.6, p.2180-2195, 1988.

SMITH, C.H. et al. Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infi ltration in human skin. J. Immunol., v.151, n.6, p.3274- 3282, 1993.

SNIJDELAAR, D.G. et al. Substance P. Eur. J. Pain, v.4, n.2, p.121-135, 2000.

SZALLASI, A. et al. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat. Rev. Drug Discov., v.6, n.5, p.357-372, 2007.

TAIWO, Y.O. et al. Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system. Neuroscience, v.32, n.3, p.577-580, 1989.

TRACEY, D.J. et al. Aspartate-like immunoreactivity in primary afferent neurons. Neuroscience, v.40, n.3, p.673-686, 1991.

VANE, J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol., v.231, n.25, p.232-235, 1971.

VERRI JR., W.A. et al. Antigen-induced infl ammatory mechanical hypernociception in mice is mediated by IL-18. Brain Behav. Immun., v.21, n.5, p.535-543, 2007.

VERRI JR., W.A. et al. Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development? Pharmacol. Ther., v.112, n.1, p.116-138, 2006.

VERRI JR., W.A. et al. IL-15 mediates immune infl ammatory hypernociception by triggering a sequential release of IFNgamma, endothelin, and prostaglandin. Proc. Natl. Acad. Sci. USA, v.103, n.25, p.9721-9725, 2006.

WALL, P.D. The laminar organization of dorsal horn and effects of descending impulses. J. Physiol., v.188, n.3, p.403-423, 1967.

WATKINS, L.R. et al. Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia. Brain Res., v.692, n.1-2, p.244-250, 1995.

WILLIS, W.D.; COGGESHALL, R.E. Sensory mechanisms of the spinal cord. New York: Plenum, 1991.